Pharmacokinetics

Pharmacokinetics_1

PSK is present in the form of stable large molecules in blood, lymph and bile of tumour-bearing mice within 4 hrs after oral ingestion whereas smaller molecules are largely degraded in the digestive system66.

The intact stable molecules are detectable in the bone marrow, spleen, brain, liver, mucosal tissues, pancreas and tumour tissue. About 70% is lost by expiration at 24 hrs and 30% in the urine after 72 hrs following ingestion66.

SPACE

Drug Interactions

PSK does not interact with other drugs nor affect drug-metabolizing enzyme activities in the liver,67 indicating that PSK has no effect on the efficacy of other drugs when taken with PSK.