Gastric cancer

A well-designed multicentre trial published in the Lancet reported that patients (n=129) with Stages I-IV gastric carcinoma receiving a standard dose of PSK (3g/day) for 4 weeks alternating with chemotherapy for 10 cycles following curative resection of cancer significantly improved both the 5- year survival (70.7% vs 59%, p=0.044) and the disease-free survival rates (73% vs 60%, p=0.047) compared with those receiving chemotherapy only (n=124)59. Based on the results, the investigators recommended the addition of PSK to standard chemotherapy for resected gastric cancer.

In a retrospective study of 872 patients with gastric cancer, abnormal levels of carcinoembryonic antigen (CEA) and acute phase reactants (APR) were associated with better survival with PSK than those without PSK (29.3% vs 6.9%: p <0.0015)60. CEA-positive patients receiving PSK therapy showed a significantly better survival rate than those without PSK (38.1% vs 18.6%, p=0.0136)60.